Liquid Biopsy Matches Medicine to the Cancer

Liquid Biopsy Matches Medicine to the Cancer Liquid Biopsy Matches Medicine to the Cancer Liquid Biopsy Matches Medicine to the CancerWhile Mayo Clinic physicians have about 30 different drugs available to them to slow prostate cancers progression, matching patient to therapy is far from a one-size-fits-all solution. But Mayo physicians hope that will soon change.Right now, doctors determine the medication that will work the best against a particular patients prostate cancer, administer the drug, and continue to test to see if its working. Even when a therapy works, ongoing tests are still needed to ensure tumors havent mutated and to make the medicine ineffective.Clinicians wanted an easy test patients take every day, with minimal pain, and get quick results. Based on the biomarkers tumors shed in the blood, patients could tell if their current medical regime was working, if they needed to try another medication and, if so, which one would work best against their particular prostate cancer biomarkers.So Mayo researchers are collaborating on research that would use biomarkers shed in blood along with nanotechnology to characterize tumors and monitor how they grow.In response, researchers are developing noninvasive genomic liquid biopsies.The patient would use a finger stick to collect a drop of blood into a cartridge that would be mailed to the laboratory, says Brian Cunningham, professor of electrical and computer engineering, bioengineering at the University of Illinois.Assistant Professor Andrew Smith, left, and post-doctoral student Sung Jun Lim at work on cancer-detection technology. Image University of IllinoisThe schools Macro and Nanotechnology Laboratory, which Cunningham directs, and its Carl R. Woese Institute for Genomic Biology are collaborating with the Mayo Clinic on the project.Perhaps the greatest advantage is that monitoring could be done daily via a simple blood test that could be done at health clinics or diagnostics labs or even at home, Cu nningham says.Doctors usually take MRIs or other imaging tests several months after a drug therapy has started, to see if tumors or growing or shrinking in response.Why wait six months after patients start a drug to take an MRI leumund to measure tumors, when you could find out if a drug is working so much sooner? Cunningham says.Doctors would like to draw a sample from the patient every day when they start undergoing chemo to watch biomarker levels and see how they change from one day to the next, he adds. If the treatment is being successful, theyll see biomarker levels go down.Testing could be done inexpensively on a desktop-sized instrument that might cost several thousand dollars, he adds. The equipment would be used to look for biomarker molecules known as micro and messenger RNA that tumors shed in the blood of cancer patients. Scientists have only recently been able to test for RNA in the blood, and the accuracy has been poor, Cunningham says.The University of Illinois techn ique improves that accuracy with nanoparticles, he adds.There may be only 500 to 1,000 of these molecules present in a drop of blood, so being able to identify them requires ultra-sensitive detection approaches, Cunningham says.If we have 30 different messenger RNA sequences were looking to detect, we can see the molecules weve collected and count and differentiate them all within a single test, he adds.But how to identify those molecules?Another university researcher, Andrew Smith, is at work on methods to call out the molecules by binding them with the surfaces of nanoparticles, specifically semiconductor quantum dots that are extremely bright and thus highlight the messenger RNA. A photonic crystal attached to the dot amplifies the RNA signal. Smith is assistant professor of bioengineering at the universitys Micro and Nanotechnology Lab.With the dots, we can see the molecules we collect, he says. The nanoparticles used are so bright they act as tiny little flashlights.After the p atients messenger RNA is separated from other components of their blood sample, technicians use an enzymatic method to place biotin on that messenger RNA. The quantum dot is attached to the biotin. Then images are taken.If you look in a microscope you can literally see individual molecules, Cunningham says. You see them on a cell phone camera if you have the microscope lens attached.The nanoparticle-tagged molecules would be counted and separated via signal-to-noise ratio, which compares the level of a desired signalfrom the semiconductorto the level of background noise.The number of amount of a particular sequence within the sample would let doctors know whether tumors are sloughing off more materiali.e. growingor lessshrinking. They can then choose to maintain the current medical regime or choose another one.Currently the liquid biopsy method is under trial at the Mayo Clinic. At the same time, the researchers are creating a simple microfluidics device that would allow the method to be used for quick, accurate diagnosis.The device could be available to physicians within five years, depending on FDA trials and tests, he says.Jean Thilmany is an independent writer For Further Discussion With the dots, we can see the molecules we collect, he says. The nanoparticles used are so bright they act as tiny little flashlights.Prof. Andrew Smith, University of Illinois

Thinking were being paid fairly matters more than making a fair wage

Thinking were being paid fairly matters mora than making a fair wageThinking were being paid fairly matters more than making a fair wageHow you feel about how your company pays you matters much more than the hard numbers of your paycheck, according to anew survey of more than 500,000 employeesby the salary databasePayScale.The survey found that employees believing they had a fair and transparent pay process had 5.4 times the impact on how satisfied employees felt at their company, compared to whether the employee was actually being paid at market value for their role.In other words, were much more sensitive to why and how were being paid than what were being paid.Why fair and transparent salaries are so importantWhy does so-and-so get paid more than I do? How do raises happen on my team?When employees know the answers to these questions, they feel like they have more agency over their careers.As any highly paid yet miserable employee recognizes, the zeroes in our paychecks dont comfo rt us as much as feeling appreciated and valued by our employers.Our study shows that just by having an open dialogue about the pay process and employees contributions at the company, employers can ultimately drive better outcomes for their businesses,Lydia Frank, PayScales Vice President of Content Strategy said.We often dont know if were fairly paidAnd the survey found that we could use all the help we can get with clarifying pay processes, because many of us are bad at estimating if were being paid fairly. Of the people the survey found were being underpaid at their jobs, almost 90% thought they were paid at or above market rate.What companies should knowBeing transparent about pay doesnt just keep employees engaged at work - it helps to ensure that they are being compensated equally. Advocates of closing the gender gemeinsame agrarpolitik argue that being transparent about pay is key to stopping the persistent gap between mens and womens salaries. When your company conducts reg ular pay audits, they can change behaviors and stop unconscious biases between teams.This study shows us that we care more about processes more than results when it comes to our salaries. To keep us engaged at work, employersdont just need to have the right answers, they need to show the rest of the class how they got to that number.

Customize this Outstanding Historians Resume Template

Customize this Outstanding Historians Resume TemplateCustomize this Outstanding Historians Resume TemplateCreate ResumeReagan Townsend100 Main Street, Cityplace, CA, 91019 H (555) 322-7337 C (555) 322-7337 example-emailexample. Professional SummaryCommunity college instructor with over eighteen years fulltime experience. Specialty areas include teaching various courses in U.S. history, cowboyfilm Civilization, political science and geography as well as serving on hiring and assessment committeesSkillsCourse planningwriting syllabi and course outlinesCreative instruction styleOrganized and detailedPersonable and approachableCharismaticFluent in SpanishExtensive knowledge of U.S. history, western civilization, political science, and geographyClear communicator of complex ideasCulturally-sensitiveEnthusiasticPositive learning environmentExperience with special-needs studentsExperience with instructional designStrong collaboratorDiverse classroom settingsManaging classroom for diverse po pulationsWork Historysocial science instructor Butler Community College El Dorado, Kansas 08/1995 Current taught courses in geography, U.S. history, Western Civilization, World Civilization, and political science as well as serving on numerous hiring committees, an assessment committee, professional employment evaluation task force, and a northcentral accreditation committeeteacher Andover Unified School District Andover, KS 08/1994 05/1995 taught three classes of geography to freshmen high school students, coached tennis and softball, and sponsored a scholars bowl teamadjunct instructor Newman University Wichita, Kansas 06/1993 08/1995taught courses in American Business History and American Foreign Relationslecturer Wichita State University Wichita, KS 01/1993 05/1993 taught a course in World Civilization to approximately forty students while I completed my Masters degree in history.teacher Wichita Unified School District Wichita, KS 01/1989 06/1990 taught world history, U.S. history, geography, and current events classes to high school freshmen, sophomores, and juniors at Wichita Northwest High SchoolEducationMaster of Arts History Wichita State University Wichita, Kansas 1993Bachelor of Science secondary education social studies University of Wisconsin-Madison Madison, WI 1987Customize ResumeMore Social Sciences Resume TemplatesExperienced Administration Resume Templates

This Wacky Cover Letter Scored Me My Dream Job

This Wacky Cover Letter Scored Me My Dream JobThis Wacky Cover Letter Scored Me My Dream Job If tzu siches one way to make a recruiter yawn, its submitting a dry, dull cover letter thats essentially a reworked version of your resume. Your cover letter shouldnt just be a list of your skills and experience - its an opportunity to highlight who you are as a person, and what makes you different from all of the other candidates who are vying for the same position as you. You want to strike the right balance between professional, passionate, and creative . But what does that actually look like on paper?Kaitlin Westbrook, a content writer and digital marketer at Eezy.com , seems to have struck just the right balance. Rather than a traditional cover letter, she applied for her current position with a cover letter formatted to look like a clickbait article, sensational headline and all. While we cant guarantee this is the right approach for every job opening out there, it certainly welches for Westbrook - not long after she submitted her cover letter, she scored her dream job.We reached out to Westbrook to hear her take on why she thinks her approach worked so well, what she learned from it, and what advice she has for other job seekers trying to catch the attention of recruiters and hiring managers .Glassdoor Can you tell us a little bit about your background?Kaitlin Westbrook I do content writing and marketing at Vecteezy , an online tech startup that provides resources for graphic designers and other creatives.When I applied for my position with Vecteezy, I welchesnt in the best place. I was doing contract work as a customer service representative, and because it was contract work, I knew it wasnt going to last forever. I was ready to pursue something that utilized my strengths in a way my current job didnt.Long story short, I was applying for a lot of things that didnt seem to pan out. Meanwhile, my contract was about to end soon, and I was worrying about rent and bills and where my future paychecks would come from. Then, an illustrator friend posted a Vecteezy position on Facebook. I knew right away I wanted it, but I wasnt sure what the best plan of action would be.Glassdoor How did you come up with the idea for a clickbait cover letter?Kaitlin Westbrook Like any younger sibling, I called up my older sister to ask for advice. Shes an art director, so shes always asking, How can you do this more creatively? So, we started discussing my cover letter, brainstorming different ideas on how to make it stand out. I wanted a writing job , so we broke it down write a cover letter that advertises writing. Instead of a typical cover letter, I wrote clickbaiton why the company should hire me. Once I wrote it, I submitted it and hoped I hadnt made a mistake.Glassdoor Submitting a cover letter like this is definitely a leap of faith. Why do you think it worked so well?Kaitlin Westbrook I was applying for a senior level posit ion with only some copywriting experience under my belt. So, while I really wasnt qualified for a senior level position, I think the company saw I really wanted to work for them and that I was willing to hustle. ??With that in mind, they were able to offer me a content writing position that also involved marketing. I honestly think they appreciated seeing someone with drive.Glassdoor I also saw that you pointed out a grammatical error in your cover letter - thats pretty gutsyKaitlin Westbrook The job listing required me to point out a grammatical error and include my favorite food in the cover letter. (I would never correct someones job listing otherwise) ??I really tried to go above and beyond, and I think that showed.Glassdoor What advice would you give to job seekers looking to spice up their cover letters?Kaitlin Westbrook This experience taught me professional risks can be worth it. Employers want professionalism and creativity, so its certainly a balancing act, but I woul d definitely try it again. I would encourage job-seekers to consider how they can be professional and mucksmuschenstill take risks, whether its in the cover letter, the resume, or something else. The right place will appreciate the creativity.

Secrets About Words to Use on Resume Revealed

Secrets About Words to Use on Resume Revealed An applicant with a close match of keywords utilized in their job application with the ones utilized in the work ad is going to have greater probability of being hired. The keywords will catch their eye so that they know where to search for the information that they want and your odds of selection is dramatically improved The manner in which you express yourself is as crucial as the information that you attempt to convey. In addition, theres an option for them to add pages to the website. Why Almost Everything Youve Learned About Words to Use on Resume Is Wrong Keywords ought to be used throughout your resume, and not only in the skills section. Utilizing both enables you to be covered either manner. Managing personal SEO isnt an insurmountable aim. Stating a statistic of geschftliches miteinander growth indicates the possible employer what you have to give and exactly what youre capable of offering. Whether youre asking for a position in the private, nonprofit, or government sectors, being in a position to recognize and utilize key words is a vital skill. Based on the essence of the job, it may be any variety of words or word combinations that indicate you might have the abilities and experience required for the job. If youre applying for work in communications, its extremely important to use action words. Another important consideration to consider is to relate the way your previous experiences would benefit the target company. Therefore, if youre actively on the lookout for employment, its probably worth signing up for the completely free month. Your resume is exactly the area you want to brag about what an awesome professional youre. You may register for a completely free month. Theres a need to switch up a number of the common words when updating your resume. When writing your job descriptions you need to be mindful in regards to the word tense. Theres also a control for uploading images t o be utilized in the rich text editor. Use clear formatting Double-check what you simply wrote to make certain it looks the exact same as the remainder of your resume. Resume action verbs may have a constructive and memorable effect on the readers memory. Utilizing action verbs and active voice makes a big difference in your resume, therefore its well worth the additional work. Utilizing action words is truly important here. The action word extracted, on the flip side, carries far more power. Hiring managers want to scan your resume and discover the information that they need in record time so that they are able to move on to the next resume. Hiring agencies will try to find particular terms in your resume to make certain you have the experience theyre seeking. Resumes should demonstrate what you could do and not what you cant do, states Harrison. A resume shouldnt read exactly enjoy a work description but more like an answer to a work description. Jobs continue to attract a lot more applicants than busy hiring departments have the opportunity to interview. Tailor your resume to the particular job. The 30-Second Trick for Words to Use on Resume The new normal is to create longer resumes that enable you to incorporate the keywords and phrases you will need to go noticed. In a lot of the situations, the distinction is being made by utilizing the appropriate keyword phrases in your resume and using them right. If youre able to strategically place an appropriate keyword in place of a current word choice great Utilizing social networks smartly is a simple easy approach to develop into find-able, so long as you concentrate on your keywords and phrases.bedrngnis utilizing the correct keywords and phrases in your job application is among the most frequent mistakes folks are doing when writing a rsume. There are a few kinds of resume keywords. The very first place to discover keywords to utilize in your resume is the work ad. Begin a work search to get the keywords and phrases you will need, then upload your new resume to Monster. Possessing a well-prepared resume is a great method to sell yourself. As you may get dinged by means of a recruiter for writing definately when you intended to say definitely, at least they will be able to work out what youre attempting to say. The words you opt to utilize in your resume are an integral way to prove your strengths. Everyone can call himself a tough worker.

What Everybody Is Saying About Udemy - Resume Secrets Get More Interviews by Better Resume Writing Is Dead Wrong and Why

What Everybody Is Saying About Udemy - Resume Secrets Get More Interviews by Better Resume Writing Is Dead Wrong and Why If dont have any work experience, references associated with your academic achievements could be a fantastic assistance. There are lots of techniques whom I have never considered while conducting a work hunt. Trainees attempting to acquire a work. Pupils looking for a teaching fellowship. New Ideas Into Udemy - Resume Secrets Get More Interviews by Better Resume Writing Never Before Revealed Your prospective employer may take a look at your work experience, in the very first location. And you can receive this whole course for the little investment of just $199.99. To locate a good job having a more comfortable salary, you will need to compose a powerful resume. The Good, the Bad and Udemy - Resume Secrets Get More Interviews by Better Resume Writing Potential employer reads information about a particular person instead of only a plain impersonal biograp hy. Targeting your resume to every employer is about more than simply highlighting the vital facts. No one would like to read overlong sentences. Dont use personal pronouns. Top Choices of Udemy - Resume Secrets Get More Interviews by Better Resume Writing With other resume services and career sites which simply accept resume writers and allow them to write in whatever style they wish, you can receive a good writer or you might wind up getting one weve rejected. Theres so much details on resumes, that in the event that you read 30 distinct sources, you will probably discover 30 unique opinions. Except in the event youre obtaining a slew of interviews when searching for work and all companies wants to hire you, you are likely to eliminate these job opportunities continually from different individuals who gets interviews and get hired. Many other specialists trying to alter business. Its important to select a font and font size thats legible and leaves enough white space on the webpage. As soon as its only a page or two in length, a resume is among the most important pieces of a work application. Pick the most suitable font and size. What Does Udemy - Resume Secrets Get More Interviews by Better Resume Writing Mean? You thought a lot about your career, decided it was a great time to look for employment, then focused on your target. A fantastic job is the secret to living a joyful life. Highly competitive people with wonderful expectations, extensive expertise, desire for prosperity, and an urge to get a better job live in this kind of aggressive world. Christopher Taber A great job is the secret to living a joyful life. ansicht sample resumes will supply you with examples of resume formats that will do the job for virtually every form of job seeker. The electronic type of your resume must satisfy some standards that were necessitated by the a variety of databases and email systems. Electronic types of your resume (e-resumes) must meet stand ards which are required by several databases and Internet websites, or else it is going to be rejected. Do not count on the spell checker. Begin by reading through the work advertisement to have a great sense of what the provider is searching for. Use the checklist to be certain you have included all appropriate data in your resume. Now its time to eliminate a number of the fluff and unnecessary information so that your very best content can stick out Everything else out theres fluff.